CD99 polymorphisms significantly influence the probability to develop Ewing sarcoma in earlier age and patient disease progression
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چکیده
منابع مشابه
CD99 polymorphisms significantly influence the probability to develop Ewing sarcoma in earlier age and patient disease progression
Ewing sarcoma (EWS), the second most common primary bone tumor in pediatric age, is known for its paucity of recurrent somatic abnormalities. Apart from the chimeric oncoprotein that derives from the fusion of EWS and FLI genes, recent genome-wide association studies have identified susceptibility variants near the EGR2 gene that regulate DNA binding of EWS-FLI. However, to induce transformatio...
متن کاملCD99 inhibits neural differentiation of human Ewing sarcoma cells and thereby contributes to oncogenesis.
Ewing sarcoma (EWS) is an aggressive bone tumor of uncertain cellular origin. CD99 is a membrane protein that is expressed in most cases of EWS, although its function in the disease is unknown. Here we have shown that endogenous CD99 expression modulates EWS tumor differentiation and malignancy. We determined that knocking down CD99 expression in human EWS cell lines reduced their ability to fo...
متن کاملMicrosatellites with Macro-Influence in Ewing Sarcoma
Numerous molecular abnormalities contribute to the genetic derangements involved in tumorigenesis. Chromosomal translocations are a frequent source of these derangements, producing unique fusion proteins with novel oncogenic properties. EWS/ETS fusions in Ewing sarcoma are a prime example of this, resulting in potent chimeric oncoproteins with novel biological properties and a unique transcript...
متن کاملTargeted Imaging of Ewing Sarcoma in Preclinical Models Using a Cu-Labeled Anti-CD99 Antibody
Purpose: Ewing sarcoma is a tumor of the bone and soft tissue characterized by diffuse cell membrane expression of CD99 (MIC2). Single-site, surgically resectable disease is associated with an excellent 5-year event-free survival; conversely, patientswith distantmetastases have a poor prognosis.Noninvasive imaging is the standard approach to identifying sites of metastatic disease. We sought to...
متن کاملTargeted imaging of Ewing sarcoma in preclinical models using a 64Cu-labeled anti-CD99 antibody.
PURPOSE Ewing sarcoma is a tumor of the bone and soft tissue characterized by diffuse cell membrane expression of CD99 (MIC2). Single-site, surgically resectable disease is associated with an excellent 5-year event-free survival; conversely, patients with distant metastases have a poor prognosis. Noninvasive imaging is the standard approach to identifying sites of metastatic disease. We sought ...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2016
ISSN: 1949-2553
DOI: 10.18632/oncotarget.12862